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A 2016 review and analysis of randomized controlled trials found that a 90% diosmin preparation significantly reduced leg and ankle edema and lower leg pain (Martinez-Zapata 2016)
This addition targets systemic inflammation through NF-kB inhibition, fundamentally changing the therapeutic profile
A., Cavelaars A
Stability considerations specific to DSIP DSIP is a short, linear, unmodified peptide with no cyclization, no D-amino acid substitutions, and no C-terminal amidation the modifications that confer stability in engineered peptides
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